The degranulation process in a Mast cell. 1 = antigen; 2 = IgE; 3 = Fc?RI; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - Mast cell; 7 - newly formed mediators (prostaglandins, leukotrienes, thromboxanes, platelet-activating factor)

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The degranulation process in a Mast cell. 1 = antigen; 2 = IgE; 3 = Fc?RI; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - Mast cell; 7 - newly formed mediators (prostaglandins, leukotrienes, thromboxanes, platelet-activating factor)